Fundamental science and clinical medicine. Fundamental Science and Clinical Medicine Fundamental and Clinical Medicine

BASIC SCIENCE AND

CLINICAL MEDICINE

Tenth All-Russian

young researchers
"Man and his health"
St. Petersburg

The Russian Academy of Sciences
Scientific Council of the Russian Academy of Sciences for Physiological Sciences

St. Petersburg Scientific Council on Problems
biology and medicine
Federal Agency for Education of the Russian Federation
Saint Petersburg State University
Faculty of Medicine
Russian Physiological Society
them. I.P. Pavlova
St. Petersburg City Palace of Youth Creativity

FUNDAMENTAL
And
CLINICAL MEDICINE
Tenth All-Russian

biomedical conference

young researchers

"Man and his health"

St. Petersburg
Organizing committee

Chairman S.V. Petrov, MD, Professor

Deputy Chairmen N.P. Veselkin, Corr. RAS

O.V. Fionik, Candidate of Medical Sciences, Associate Professor
Members of the organizing committee E.K. Aylamazyan, Academician of the Russian Academy of Medical Sciences

Yu.V. Natochin, Academician of the Russian Academy of Sciences

N..N. Petrova, MD

Program Committee A.V. Balakhonov, Ph.D., Associate Professor

L.G. Magazanik, Corresponding Member RAS

YES. Niauri, MD, Professor

A.G. Obrezan, MD, Professor

N.N. Petrova, MD

O.V. Fionik, Candidate of Medical Sciences, Associate Professor P.K.

L.P. Churilov, Candidate of Medical Sciences, Associate Professor

S.D. Sheyanov, Doctor of Medical Sciences, Professor

A.N. Shishkin, MD, professor

M.V. Erman, MD, Professor

PC. Yablonsky, MD

Editorial board I.P. Mavidi, PhD

E.R. Khalitova

INTERRELATIONSHIP OF CLINICAL

AND CYTOGENETIC DISORDERS

IN CHILDHOOD CEREBRAL PALSY

D.V. Abdullatypova, class. ord.

Kazan State Medical University,

Department of Neurology, Neurosurgery with a course medical genetics. Kazan, Russia
Objective: to study the relationship between clinical and cytogenetic disorders in cerebral palsy (CP).

Research material. Examined 71 children with various forms cerebral palsy and 40 healthy individuals. The study included children with intact intelligence studying in a specialized boarding school for children with cerebral palsy. All patients were divided into clinical forms of the disease: hyperkinetic - 13 people. (18.3%), hemiparetic - 25 people. (35.2%) and spastic diplegia - 33 people. (46.5%).

Research methods: 1) clinical and neurological, including a scoring of the severity of 22 clinical indicators of motor disorders, each of which was estimated from 0 to 5 points; 2) micronucleus test, with the study of 20,000 erythrocytes in a peripheral blood smear from each patient and the identification of the number of erythrocytes with micronuclei (EM), expressed as a percentage; 3) statistical.

Results. The scoring of the severity of clinical manifestations of cerebral palsy revealed that the most severe changes in self-service, motor deficit, sensory functions are significantly more often detected in children with hyperkinetic form of cerebral palsy, compared with other forms (p The severity of the disease significantly prevailed in girls compared to boys, patients with spastic diplegia, (r

The average values of EM in all forms of cerebral palsy significantly exceeded the spontaneous level of cytogenetic disorders in the control group 0.21% and 0.08%, respectively (p

The obtained preliminary data suggest a more severe suffering of girls with cerebral palsy, while it is known that the disease is more common in boys. Gender differences are clearly seen in diseases of a multifactorial nature. Since, with multifactorial inheritance, the severity of the disease in a rarely affected sex manifests itself more rudely, with a certain degree of probability, cerebral palsy can be attributed to a pathology with polygenic inheritance. Undoubtedly, these proposals require additional research in this direction.

PECULIARITIES OF THE PERFORMANCE OF SPECIFIED MOTOR ACTIONS WHEN LEFT-HANDED AND RIGHT-HANDED PERCEPTIONS OF DIFFERENT NATURE FEEDBACK

A.P. Abramova, student

Tver Gymnasium No. 44. Tver, Russia
Most human activities are associated with the perception and processing of information. Given the presence of dominance of one of the hemispheres, a problem arises: what are the features of motor actions during the perception of verbal or formalized information in people with different leading hemispheres.

Purpose: to analyze the difference in the performance of precision movements when left-handed and right-handed people perceive information feedback of a verbal and formalized nature.

The study is based on the kinematometry method, which allows to quantify the musculo-articular sensitivity. The study included two series of experiments. First episode. Left-handers and right-handers recorded fidelity right forearm of a given angle of 45 degrees on a horizontal kinematometer. The position of the forearm is fixed at a given angle with visual control. Then the subject, with his eyes closed, reproduces the given angle 5 times under the following conditions: a) without informing the subject of the result of the action; b) with the message to the subject of the result of the committed action in verbal form, using the words "more"- when the specified angle is exceeded, "smaller"- in case of shortfall to a given angle and "exactly"- at exact reproduction of the set angle; c) with the message to the subject of a specific (formalized) result of the action - for example, - "42 degrees". Second series experiment included the repetition of these experiments, but when played by left-handers and right-handers, the movement left forearms at a given angle of 45 degrees.

The results of two series of experiments show that right-handers and left-handers equally poorly perform precision movements based on proprioceptive information, and feedback in the form of a subjective sensation of muscle tension is insufficient to correct the motor action. The presence of interhemispheric functional asymmetry of the sensory type determines the difference in the perception of verbal and formalized information feedback by left-handers and right-handers: during actions with the dominant hand, verbal information is better perceived by right-handers, and formalized information by left-handers. The degree of feedback formalization affects the accuracy of correction when performing given motor actions: the higher the level of feedback formalization, the more accurate the subsequent action.

INFLUENCE OF SOME RISK FACTORS OF EARLY DYSONTOGENESIS ON MEMORY DEVELOPMENT IN HIGH SCHOOL STUDENTS

M.A. Abramova, stud.

Pomor State University

them. M.V. Lomonosov, Faculty of Psychology, Department of Psychology. Arkhangelsk, Russia

The need to analyze the causes of possible deviations and organize individual corrective assistance to high school students during their development is most relevant, because. in early adolescence, important processes occur associated with the restructuring of memory (Leontiev A.N., 1931, Rean A.A., 2003). The purpose of our work is to identify the influence of risk factors for early dysontogenesis on the development of memory in children aged 15-16 years.

During scientific work 24 people aged 15-16 years (12 boys and 12 girls) studying in high school No. 50 in Arkhangelsk and who did not have a history of severe neurological disorders. At the first stage of the study, the most common risk factors for early dysontogenesis in high school students were identified using a questionnaire developed at the Research Institute of Age Physiology of the Russian Academy of Education. At the second stage, methods were selected that allow for a comprehensive assessment of the psychophysiological development of memory in an individual child: the “10 words” test (auditory short term memory), Bernstein test "9 geometric shapes"(short-term visual memory), a method of reproducing differently perceived words (the leading type of memory).

The study of the level of psychophysiological development of children aged 15-16 indicates that the majority of high school students are characterized by age-appropriate volume of short-term auditory (75.00±1.46% of children) and visual memory (83.33±1.54% of children). In most adolescent children, the leading types of memory are combined (41.67±1.09) and visual (20.83±0.77).

A survey of parents of high school students revealed that 83.33±1.54% of children have risk factors in early development: toxicosis of the first half of pregnancy, mother's age, artificial feeding of a child from birth, adoption medicines during pregnancy, maternal morbidity during pregnancy.

In high school students with a history of risk factors for early dysontogenesis, indicators of the level of memory development are lower than in children without risk factors. So, in the experimental group with a large number of risk factors in early development, the volume of short-term auditory and visual memory is 2 times less compared to children in the control group (50% and 100%, respectively).

Features of the influence of hypothermia on the force of contraction of the ground squirrel's heart.

The role of calcium homeostasis

A.S. Averin, Ph.D., E.V. Aleshkevich, student, S.V. Tarlachkov, stud.

Institute of Cell Biophysics RAS, Laboratory of Mechanisms of Natural Hypometabolic States. Pushchino, Russia
A serious medical and biological problem is a violation of the contractility of the heart during cooling. The myocardium of hibernating animals is a unique model for studying the mechanisms that ensure its functioning under conditions of body temperature drop from 37 to 0 ° C. This ability indicates a special plasticity of calcium homeostasis in the heart of hibernating animals, the mechanisms of which are still unclear. The response of the contraction force to a change in the stimulation frequency (frequency-force dependence) and the introduction of a pause against the background of heart stimulation with a constant frequency (rhythmoinotropic ratios) are widely used to assess the contribution of various calcium transporting systems to the regulation of the contraction force of cardiac cells. It is shown that the nature of rhythminotropy largely depends on temperature. In this work, we studied the effect of the temperature of the perfusion solution (from 37 to 4°C) on the frequency-force dependence (in the range from 0.1 to 1.0 Hz) and the effect of a pause in the ground squirrel’s heart in different functional states of animals (activity, hibernation, entering hibernation, awakening). For the first time, 2 main types of reaction to a decrease in temperature were found in hibernating animals. In most active animals, when the temperature drops from 30 to 5 ° C, the “frequency-force” dependence becomes positive from negative, the contraction force increases, and the potentiating effect of the pause disappears. In sleeping animals, the "frequency-strength" dependence remains negative over the entire range of temperatures studied, the force of contraction decreases, and the potentiating effect of the pause remains and even increases. The study of the dependence of rhythmoinotropic characteristics on extracellular calcium in combination with the use of blockers of various calcium transporting systems showed that in all the studied groups of animals, the contraction force at low temperatures (5 ° C) significantly depends on extracellular calcium.

CHANGES IN ELECTROCARDIOGRAM AND HEART RATE VARIABILITY

FOR EMERGENCY WORKERS

DURING THEIR PROFESSIONAL ACTIVITIES

K.A. Alekseev, stud.

Novgorod State University Yaroslav the Wise

Institute of Medical Education,

Department of Normal Physiology. Velikiy Novgorod, Russia
Long-term motivational-emotional stress in people during the working day (including forms of professional stress among doctors and other medical workers) is expressed in "mental and physiological reactions to a wide range of situations in work" (V.A. Vinokur, O.V. Rybina., 2004). At the same time, a well-known dependence is observed: the more intensely a medical worker works, the more actively he avoids thoughts and feelings associated with professional stress. In connection with the foregoing, it was of interest to identify changes in the nature of the ECG and HRV (heart rate variability) in employees of the ambulance station during the daily duty. The observations involved 25 people (10 men and 15 women) aged 25 to 60 years with different levels of self-esteem. The study was carried out at the ambulance station in the city of Pskov. To determine changes in the nature of the ECG and HRV, the method of daily Holter monitoring was used, and for self-assessment of the personality, the questionnaire of V.K. Gerbachevsky was used. The main attention in the study was focused on identifying the "physiological cost" of the implementation of the features of the motivational spectrum of activity of the subjects during the work shift in terms of their cardiovascular functions. In general, when analyzing the ECG and HRV parameters in the subjects of 5 groups, 3 main variants of the dynamics of the motivational-emotional spectrum of activity and associated shifts in the activity of the heart were identified. Option 1. Preservation of "arbitrarily - constructive" trends in production activities during the work shift. The appearance of single supraventricular extrasystoles was noted, and a decrease in the ST interval (no more than 2 mm) was detected. Option 2. The transition of "arbitrarily - constructive" tendencies to "emotionally - reactive". In the subjects on the ECG, the changes were characterized by the appearance of a negative T wave. Option 3. Preservation of "emotionally reactive" tendencies in the course of current activities. Single supraventricular extrasystoles were recorded on the ECG. The data obtained testify to the high sensitivity and extreme diversity of the dynamics of the studied psychophysiological indicators in people in the process of performing their production activities.

Autoimmune reactions of lymphocytes in patients

with acute and chronic cerebral ischemia

E.V. Andrianova, class. ord., A.A. Baitelieva, Researcher,

T.V. Kim, stud., M.V. Sotnikova, stud.

Kyrgyz-Russian Slavic University, Faculty of Medicine, Department of Special Clinical Disciplines No. 2.

Institute of Molecular Biology. Bishkek, Kyrgyzstan
In the mechanisms of vascular damage, autoimmune reactions to phospholipids are important. Sensitization to them can contribute to the development of atherothrombosis. However, the state of cellular reactions to phospholipids and their diagnostic significance in cerebrovascular pathology remain poorly understood.

We examined patients with acute and chronic cerebrovascular insufficiency: ischemic stroke (IS) and stage II and III dyscirculatory encephalopathy (DE). The diagnoses of IS and DE were based on generally accepted criteria; in doubtful cases, neuroimaging and examination of the cerebrospinal fluid were performed. The cytotoxic effect of sensitized lymphocytes (CTEL) was studied according to the method of V.L. Morozov modified by M.I. Kitaev.

The study of CTEL with cardiolipin in the group of patients with IS revealed its sharp increase compared to the control (p

The results of the study indicate that in patients with cerebrovascular diseases, cytotoxic reactions of lymphocytes with cardiolipin develop, and a clear dependence of the degree of change in the indicator on the severity, localization, and stage of the process is revealed.

REGULATION OF HUMAN IMMUNOGLOBULIN J-PEPTIDE EXPRESSION IN SQUAMOUS CELL CANCER AND LUNG ADENOCARCINOMA

N.V. Antipova, stud.

IBCh RAS im. M.M. Shemyakina and Yu.A. Ovchinnikov LSFGCh.

Moscow, Russia

Lung cancer is one of the most intensively studied tumors in recent years. This disease is one of the three most common forms of cancer, and it has a high mortality rate among patients, so markers are needed to make it possible to diagnose it. In squamous cell lung cancer, an increased expression of proteins of the immune system is observed, which may be associated with the active penetration of B-lymphocytes into the area of the malignant neoplasm and the presence of a large number of antigen-presenting cells there. The protein we are studying has an immunoglobulin type of polypeptide chain folding, consists of 159 amino acids as part of a single polymer with molecular weight 15 kDa. It has been shown that the expression level of the J-peptide gene changes in various pathologies (mainly in pathologies affecting the lungs or the gastrointestinal tract). Tumor tissue samples from the central and peripheral areas of the lungs at stages I-III of the development of the disease were selected for the study and included highly and poorly differentiated forms of the tumor. In addition, we used normal tissues from the central and peripheral parts of the lungs, taken from 5 patients without visible pulmonary pathologies. It was shown that with an increase in the number of studied patients with squamous cell carcinoma and lung adenocarcinoma, regardless of the area and stage of the disease, in poorly differentiated forms of the tumor, predominantly reduced expression of the J-peptide was observed. The type of regulation of J-peptide synthesis was determined by the ratio of its content in the tumor to normal tissue (T/N) in each pair of samples. For 42% of the studied samples, a decrease in the content of J-peptide in tumor tissues is observed, an increase for 27%, and for 31% no differences were found. For the group from the central localization of a highly differentiated tumor, half of the pairs of NT samples did not show changes in the synthesis of the J-peptide, and the remaining samples were equally distributed between the regulation variants. Based on these results, it can be assumed that a poorly differentiated form of a tumor is more regulated, and in this case, transformed cells perceive external metabolic signals more easily, while a tumor containing highly differentiated cells is in an isolated, more stable state. Thus, it follows from the presented results that translation of the J-peptide in immunocytes depends on the state of the epithelium, the defeat of which by squamous cell carcinoma or lung adenocarcinoma leads to a predominantly reduced expression of this protein.

Changes in the immunoreactivity of p53 and Bcl-2

in the paraventricular and supraoptic nuclei of the hypothalamus after sleep deprivation in rats

I.V. Artamokhina, student, V.A. Belova, stud.

Institute of Evolutionary Physiology and Biochemistry

named after I.M. Sechenov RAS,

Laboratory of Comparative Somnology and Neuroendocrinology.

Saint-Petersburg, Russia
It is known that P53 and Bcl-2 proteins play an important role in the regulation of apoptosis in various tissues and, especially, in the course of nervous tissue morphogenesis. However, the expression of these proteins in neurons of various parts of the brain and, especially, in the hypothalamus, was shown in adult animals both in normal conditions and under various functional loads that did not cause neuronal death. A number of studies suggest that, in addition to the mechanisms of programmed cell death, P53 and Bcl-2 are of great importance in the regulation of neuronal activity when their functional state changes. Sleep deprivation (interruption) (DS) is a generally recognized model for studying somnogenic brain structures, which causes a state of tension in various body systems. It is known that the hypothalamus and, in particular, the paraventricular (PVN) and supraoptic (SOA) nuclei play an important role in the body's adaptation to various stress factors. In this regard, the aim of this study was to find out whether the expression of P53 and Bcl-2 in PVN and SON changes after 6 hours of sleep deprivation and subsequent 2 hours of recovery. Three groups of male Wistar rats were used in the experiment: control, after DS, and after recoil. Immunohistochemically, P53 and Bcl-2 were detected on free-floating brain sections using specific unlabeled antibodies. Was held quantitative analysis changes in the immunoreactivity of these proteins in PVN and SON, which revealed an increase in the number of P53- and Bcl-2-immunoreactive cells in both nuclei after DS and recoil. There was an increase in the optical density of P53 in the PVN compared with the control by 83% (p 0.05) after DS and by 40% (p 0.05) after recoil; in SOYA by 64% (p>0.05) after DS and by 78% (p RESULTS OF CREATING A URINARY BLADDER WITH A PART OF THE STOMACH IN PATIENTS AFTER ITS REMOVAL

ABOUT CANCER

D.N. Atmadzhev, competition candidate, A.V. Sergeev, ass., V.A. Fadeev, ass.,

O.A. Kirichenko, competition candidate, M.V. Korokhodkina, competition, O.O. Burlaka, Asp.

St. Petersburg State Medical Academy

them. I.I. Mechnikova, Department of Urology. Saint-Petersburg, Russia
Introduction: In 1954 Sinaiko E.S. reported the replacement of the bladder (BM) with a segment of the stomach. A consistently low urine pH reduces the risk of urinary tract infection, which occurs in 30% of intestinal reservoirs, and as a result reduces the risk of stone formation. Also, there is no resorption of ammonium chloride in the gastric reservoirs, thus, hyperchloremic acidosis, which is a frequent companion of intestinal reservoirs, does not occur.

Materials and methods: From 2001 to 2007 we performed 22 radical cystectomy (RC) and gastrocystoplasty (GCP). In 8 patients, GCP was performed by us in our own modifications (patent for invention No. 2204951 dated May 27, 2003). There were 16 men (72.7%), 6 women (27.3%). The age range of the patients was from 44 to 72 years. The mean age was 61.6 years.

Results: There were no deaths in the early postoperative period. Of the 22 operated patients, 3 (13.6%) had complications associated with urinary diversion and accompanied by secondary pyelonephritis. In 2 patients there was a failure of the uretero-reservoir anastomosis on one side. They underwent CPNS with simultaneous revision and drainage of urinary leakage, and subsequently antegrade stenting of the ureter was performed. In the late postoperative period up to 4 years, 18 patients after RC were available for examination. Complications were observed in 4 (22.2%) patients. All of them had hematuria-dysuria syndrome, and in 3 others a large segment of the stomach was taken (in our modification). One of these patients developed a lymphocele, the other developed a stricture of the uretero-reservoir anastomosis with the development of VUG and secondary pyelonephritis, for which percutaneous puncture nephrostomy was performed. Vesicoureteral reflux was diagnosed in one patient. Thus, satisfactory functional results were obtained in 14 (77.8%) patients.

Findings: when replacing the bladder with a segment of the stomach, satisfactory immediate and long-term results were obtained. Gastrocystoplasty is the method of choice for urinary diversion in patients with chronic renal failure and impaired urodynamics of the upper urinary tract.

NUCLEAR AND SCREEN FORMATIONS OF THE CORTICOMEDIAL GROUPING OF THE ROSTAL LEVEL OF THE ANTERIOR SECTION OF THE ALMONDAL COMPLEX OF WAG/Rij RATS

A.V. Akhmadeev, senior researcher, I.R. Garipova, Asp.

Department of Morphology and Physiology of Humans and Animals.

Ufa, Russia
The structural organization of the amygdala complex of the brain (MC, corpus amygdaloideum) is characterized by complexity, which is predetermined by the presence of a variety of principles of organization of the gray matter included in it. The key to understanding the cytoarchitectonic features of MC is the teaching of Zavarzin (1986) on nuclear and screen centers nervous system. A detailed analysis of the functional morphology of the MC, which revealed the presence of a combination of nuclear and screen principles of gray matter organization and the functional community of nuclear and paleocortical structures on its territory, made it possible to propose a new view of its structural and functional organization as a nuclear-paleocortical complex of the telencephalon (Kalimullina, 1991).

The term "anterior section" denotes the territory of the MC located at the level of the anterior cortical nucleus. Wistar rats have two parts in the anterior section: rostral and caudal (Akmaev and Kalimullina, 1993). The rostral part of the anterior segment of the MC is located at the level of the nucleus of the lateral olfactory tract, in which three layers are clearly identified. The cortico-medial grouping of this department also includes the anterior amygdala region, the anterior cortical and central nuclei, and the anterior insertion masses.

The aim of this work was to study the representation of nuclear and screen centers by studying the cytoarchitectonic features of the structures of the rostral level of the anterior MC of WAG/Rij rats. The work was performed on 10 mature rats using highly informative frontal sections of MC (Kalimullina and Kalkamanov, 1989) stained with cresyl violet.

The results of the analysis made it possible to classify the central core and intercalary masses as nuclear centers. The nucleus of the lateral olfactory tract has the characteristics of the screen center. The anterior cortical nucleus has the character of an interstitial formation. The anterior amygdala region, defined on the basis of the topographic principle, is a transitional formation.

THE POSTERIOR MEDIAL NUCLEUS OF THE ALMONDAL COMPLEX OF THE BRAIN: SEX DIFFERENCES IN DENDROARCHITECTONICS OF THE RETICULAR NEURONS

A.V. Akhmadeev, senior researcher

Bashkir State University, Faculty of Biology,

Department of Morphology and Physiology of Humans and Animals. Ufa, Russia
In the system of neuroendocrine regulation, which forms the basis of the body's integration, steroid hormones, and, above all, sex hormones, occupy a central place. They are universal inducers of a wide range of processes, ranging from gene expression to a determining effect on the morphogenesis of its systems (Akmaev, 1979, Akmaev, Kalimullina, 1993, Ugryumov. 1999, Chaliapin et al., 1995, 2005, etc.). A striking example of the latter is the so-called sexual differentiation of the brain (SDM), carried out by androgens in a certain (critical) period of early ontogenesis (Reznikov, 1982, 2004). At the present stage of development of ideas about the sexual differentiation of the brain Special attention the role of extrahypothalamic structures in this process is given. One of such structures of the telencephalon is the amygdala complex, which has powerful neural connections with the hypothalamus.

The posterior medial nucleus (Mep) is topographically located between the dorsomedial and posterior cortical nuclei. It has been shown that its neurons respond to ovariectomy and orchidectomy by changing karyovolumetric parameters (Akmaev and Kalimullina, 1982), and sex differences in neuronal binding of alpha-bungarotoxin, which is a ligand of nicotinic acetylcholine receptors, have been found on its territory (Arimatsu and Seto, 1982). Whether the morphogenetic effect of androgen is realized in the posterior medial nucleus in the period of PDM is still unknown.

The studies were carried out on Wistar rats of both sexes at the age of six months with a body weight of 300-350. The neuronal organization of Mep was studied on preparations prepared by the Golgi method. Identification of neurons was carried out on the basis of the classification of T.A. Leontovich (1978). Quantitative characteristics reticular neurons subjected to statistical processing using the program Statistica 5.5. The analysis performed revealed the presence in male rats of greater overall length dendrites (p=0.02), dendritic field area (p=0.03) and total length of terminal branches (p=0.01).

This work was supported by the Grant of the President of the Russian Federation MK-2542.2007.4.

association gene polymorphism nfatc4 with the development of myocardial hypertrophy in athletes

I.I. Akhmetov, Ph.D., Yu.V. Shikhova, stud.

St. Petersburg Research Institute physical culture, St. Petersburg.

Transcription factors of the NFAT (nuclear factor of activated T-cell) family are involved in the embryonic development of the cardiovascular system and also mediate hypertrophic signals in the myocardium. It has been shown that overexpression of the gene NFATC4 induces the development of myocardial hypertrophy in mice, while the absence of this gene is lethal for them. In the gene NFATC4 In humans, a structural Gly160Ala polymorphism was discovered, the functional role of which in the remodeling of the cardiovascular system in athletes remains unexplored. The aim of the study was to identify the association of Gly160Ala gene polymorphism NFATC4 with the development of left ventricular myocardial hypertrophy (LVH) in athletes. The study involved 72 athletes (39 men, 33 women) who specialize in rowing and speed skating all-around. Subjects' DNA was isolated from epithelial cells oral cavity alkaline extraction method or sorbent method. Genotyping was performed by restriction fragment length polymorphism analysis. Echocardiographic assessment of the morpho-functional remodeling of the myocardium of athletes was carried out on the ultrasound scanner Aloka-3500. In the total sample of athletes, the frequency NFATC4 Ala allele was 47.9%. Correlation analysis revealed in men the relationship NFATC4 Ala allele with a risk of developing LMBV: in carriers of the Ala/Ala genotype, the weight of the left ventricular myocardium was significantly greater than in carriers NFATC4 Gly allele (398 (77) g versus 328 (70) g; r=0.4, p=0.01). In addition, in men, the Ala allele was associated with higher values of the body mass index (Ala/Ala, 25.3 (1.3) kg/m2; Gly/Ala+Gly/Gly, 23.5 (1.9) kg/m2; r=0.44, p=0.005). Among women, no dependence of echocardiographic parameters on genotypes was found. NFATC4. Thus, the Gly160Ala gene polymorphism NFATC4 associated with remodeling of the cardiovascular system and body mass index in men involved in rowing and speed skating.

The role of vascular endothelial growth factor gene polymorphism in the remodeling of the cardiovascular system of athletes

I.I. Akhmetov, Ph.D., A.M. Khakimullina, Asp.

St. Petersburg Research Institute of Physical Culture. St. Petersburg.

Academy of sports and applied martial arts. Moscow, Russia
It has been established that the implementation of systematic physical activity is accompanied by adaptive changes in the form of growth of myocardial blood vessels. individual differences to the degree of such adaptive changes are due to genetic factors that determine the hereditary predisposition to perform physical activity. The identification of genetic markers associated with the regulation of the growth of myocardial vessels is an important task of sports medicine and genetics for solving many issues related to the prevention of occupational pathologies in athletes. One of the main factors directly affecting vascular growth is vascular endothelial growth factor (VEGF). Among the studied gene variations VEGF human needs to highlight the G-634C polymorphism. It is known that VEGF The C allele is expressed to a greater extent than the G allele and is associated with high aerobic endurance. For this reason, we hypothesized that VEGF The C allele is protective against the risk of developing severe left ventricular myocardial hypertrophy (LVH), which limits cardiorespiratory endurance. The aim of the study was to identify the association of G-634C gene polymorphism VEGF with remodeling of the cardiovascular system of athletes. The study involved 38 men and 33 women (members of the main and youth teams of the Russian Federation), specializing in rowing and speed skating all-around. The DNA of the subjects was isolated from the epithelial cells of the oral cavity. Genotyping was performed by restriction fragment length polymorphism analysis. Echocardiographic assessment of the morpho-functional remodeling of the myocardium of athletes was carried out on the ultrasound scanner Aloka-3500. In accordance with the hypothesis, we found an association VEGF C allele with the lowest LVMH in male skaters, which is confirmed by the differences between carriers of GG and GC genotypes according to the mass index of the left ventricular myocardium (344 (27) g/m 2 versus 281 (53) g/m 2 , p= 0.025), according to the thickness of the interventricular septum (1.35 (0.05) cm versus 1.23 (0.17) cm, p=0.019) and the thickness of the posterior wall of the left ventricle (1.47 (0.15) cm versus 1.26 (0.12), p=0.019).

THE STATE OF PROLIFERATIVE ACTIVITY IN BREAST TISSUE IN WOMEN AT RISK OF DEVELOPING BREAST CANCER AFTER OVARIECTOMY

E.N. Bailyuk, Ph.D., I.N. Kostyuchek, Ph.D., A.V. Nikolaev, stud.

St. Petersburg State University, Faculty of Medicine, Department of Obstetrics and Gynecology.

Research Institute of Obstetrics and Gynecology. BEFORE. Otta RAMN.

Saint-Petersburg, Russia
The study included 109 patients operated on for uterine fibroids aged 40 to 52 years (mean age 47.4 ± 3.8). In the process of preoperative preparation, after surgery (after 9-12 months), all patients underwent a comprehensive examination of the mammary glands (MG): assessment of the 5-year risk of developing breast cancer (BC) according to the Gale model; physical and radiological examination of the breast. In women with a 5-year risk of developing breast cancer ≥ 1.7 (n=95), regardless of the detection of nodular formations in the mammary gland, a multifocal trephine biopsy of the breast under echographic control was performed. Proliferative activity in the breast tissue was assessed by histological and immunohistochemical methods with the determination of the expression of tissue markers Ki-67 and proliferating cell nuclear antigen (PCNA). A comparative analysis was carried out depending on the volume of surgical intervention: hysterectomy without appendages (n=35), with mono- and bilateral oophorectomy (n=18 and 42, respectively). In 95 of the examined women (87.2%), the 5-year risk of developing breast cancer, calculated using the Gale model, was 1.85 ± 0.13, which was comparable to that in patients with breast cancer (1.93 ± 0.17; p
FUNCTIONAL ASYMMETRIES

ATHLETES-ARMRESLERS

S.A. Bakumenko, stud.

Kuban State University of Physical Culture, Sports and Tourism, Department of Physiology. Krasnodar, Russia
The study of the individual profile of functional asymmetry (IPA) allows finding new ways to achieve high sports results. Special requirements for the asymmetry of technology are made in arm wrestling.

47 athletes-armwrestlers were examined, at the age of 19-27 years IPA was determined by the combination of sides of dominance of motor and sensory functions according to the scheme: hand - foot - eye - ear. The asymmetry coefficient was calculated (in %) for each paired organ. The right hand dominated in 63.8% of cases, the left - in 29.8%, ambidexterity - 6.4%. The right leading leg was noted in 53.2% of the athletes, the left leg - in 40.4%, ambidexterity - in 6.4%. The dominant right and left eyes were characteristic of 85.1% and 14.9%, respectively; there was no ambidexterity of vision. The leading right ear was found in 63.9%, the left - in 34.0%, hearing ambidexterity - in 2.1%.

IPA among armwrestlers is represented by 16 variants out of 80 theoretically possible. The greatest variability was observed in the group of right-handed athletes (10 variants). "Absolutely right-handed" accounted for 34.0%. In general, right motor asymmetry was present in 44.7% of armwrestlers, sensory – in 51.1%. Mixed phenotypes with crossed motor asymmetry - leading right hand and left foot - occurred in 12.8% of cases, with crossed sensory asymmetry - leading right eye and left ear - in 10.6%, left eye and right ear - in 4.3 %.

In the group of left-handed armwrestlers, IPA variability was less (5 variants). "Absolute lefties" were 4.3%. Left motor asymmetry was observed in 25.5% of athletes, sensory - in 6.4%. In 4.3% of cases, there was a tendency to cross-motor asymmetry with the left hand and ambidexterity of the legs. Mixed phenotypes with cross sensory asymmetry - right eye and left ear - accounted for 12.8%.

The results of the study indicate the originality of IPA in armwrestlers. “Right-handed” athletes may have different variants of cross-motor and sensory asymmetry, however, “left-handed” athletes are characterized by unilateral “left” motor asymmetry - a combination of the left leading arm and leg. Sensory asymmetry is directed to the dominance of the right eye.

STUDIES OF ANTHROPOMETRIC PARAMETERS
STUDENTS OF DIFFERENT AGES

S.O. Balagurin, stud.

Karelian State Pedagogical University,

Faculty of Physical Culture, Department of Anatomy, Physiology and Hygiene with the course of OMZ. Petrozavodsk, Russia
The aim of the work was to identify patterns of changes in the anthropometric parameters of students of specialized educational institutions and comparing them with recommended values for their age.

The research was carried out in the winter of 2006-2007. 40 boys of the 5th and 6th grades of the Republican cadet boarding school in Petrozavodsk were examined. There are 20 people in each class. The mean age was 11.6±0.08 years in the younger group, 12.7±0.08 years in the older group. Functional parameters were studied (standing height, sitting height, body weight, chest circumference, dynamometry, etc.) and indicators and indices were calculated: Pignet, Erisman, proportionality, harmony, body strength, etc.

Studies have shown that there are age differences in height, weight and other indicators. Thus, the strength of the hands of sixth grade students was significantly higher: it was for right hand 15.4 ± 0.4 kg for fifth-graders versus 20.1 ± 1.17 for sixth-graders, and respectively for the left hand 13.6 ± 0.6 (5 cells) and 18.3 ± 1.1 (6 cells) kg. The age difference was 31.1% for the right hand and 34.9% for the left hand. It should also be noted that the scatter of the measured values was higher in the sixth graders compared to the fifth graders, which may indicate the emerging differences in the organisms of adolescents of different ages in this indicator.

Disproportionately long legs, especially pronounced, in senior group, as well as a disproportionately different shift in the strength of the hands and weight compared to changes in height, can be indirectly explained by the fact that the body of the older group of students has entered the stage of puberty.

It is alarming that the students of both groups, on average, are defined as weak (48-49%) in terms of body harmony, as well as in terms of body strength (Pigne's indicator) - 38.8, 48.4 c.u.

In our opinion, in general, the weight slightly deviating from the average statistics (overweight), weak and inharmonious physique can be explained by insufficient physical activity. We think that it is possible to achieve better results in these parameters by increasing physical activity, perhaps, an increase in training loads associated with physical activities, or at least a decrease in the number of hours spent in a sedentary, semi-stationary state.

AWARENESS OF THE POPULATION ABOUT THE MARKET OF MEDICAL SERVICES

S.A. Balokhin, ass., G.E. Teptin, stud.

St. Petersburg State Medical University

them. acad. I.P. Pavlova, Department of Public Health and Health. Saint-Petersburg, Russia
One of important issues that arose during the period of reform and development of market relations in healthcare is the lack and imperfection of public awareness (potential buyers) about the medical services market. Unfortunately, the Program of State Guarantees for the Provision of Citizens Russian Federation free medical care includes, among other things, only the types and volumes of medical care provided free of charge without reference to a specific list of medical services (standards) provided in the event of a particular disease. This implies the fact that a number of medical institutions (mainly state-owned) often decide on their own the procedure and list of medical services that can be provided to patients on a paid basis. Moreover, despite the main regulatory document (Decree of the Government of the Russian Federation dated January 13, 1996 No. 27 “On Approval of the Rules for the Provision of Paid Medical Services to the Population by Medical Institutions”) regulating this type of activity, they are provided in parallel with free services for the population.

Considering the above, we analyzed the opinion of patients who applied for medical care in state and non-state polyclinics on the list of medical services provided on a fee basis. A total of 200 people were interviewed. The results of the survey showed that due to the inaccessibility of free medical care, a significant part (59.7%) of the respondents believe that most services should be paid. This indicator was the highest (57.1%) among respondents under the age of 20. Among those who believed that dentistry should be paid, persons aged 20-30 years (37.5%) prevailed; cosmetology - at the age of 31-45 years (45.2%). The most positive attitude to the fact that all medical services were paid, were people with secondary education (62.5%), unmarried (50.0%), as well as people with an average monthly income of 10 to 30 thousand rubles (22.7%).

Thus, the analysis showed the readiness of a part of the population to seek paid medical care, which should be taken into account when conducting a directed marketing strategy.

The formation of the pediatric service

in Kyrgyzstan

A.M. Baltabaev, stud.

Kyrgyz-Russian Slavic University,

Faculty of Medicine, Department of Public Health and Health. Bishkek, Kyrgyzstan
Before the establishment of Soviet power, there were no medical institutions in Kyrgyzstan.

In 1924 Kyrgyzstan was transformed into the Kara-Kyrgyz Autonomous Region. Its regional department became the leading center of health care. In February 1925, a sub-department for the protection of motherhood and infancy was created at this department, which included a sub-department for the protection of children's health, which was headed at first by Z. F. Bedareva, and from July 20, 1925. - Z. F. Tukhomitskaya.

In September 1925, a maternity hospital with 20 beds was opened in the regional capital, then at the Przhevalsk and Jalal-Abad hospitals, maternity wards with 5 beds each. To serve the nomadic population in 1925. 4 mobile children's consultations were organized, where patients were registered and subsequently actively treated. Thus arose new form medical care of the population - clinical examination of patients.

In 1926, an independent department for the protection of motherhood and infancy was opened under the People's Commissariat of Health of the Kirghiz ASSR, which began to organize medical care for children of all ages. In 1926, the first children's preventive outpatient clinic began to function in Frunze.

By 1928, there were 10 mobile children's consultations and a dairy kitchen in Kyrgyzstan. During this period, the network of institutions for the protection of motherhood, infancy and childhood has significantly developed. In 1928, 8 children's consultations functioned in the republic, 3 of them - in countryside. In 1932, the first independent children's hospital with 35 beds was opened in Frunze; by 1937, the bed capacity had increased to 50. In 1936, thanks to the initiative of the talented healthcare organizer Kh.D. Yarullabekov, a regional hospital was opened in the Ton district, in which there was a women's and children's consultation. In 1938, two children's sanatoriums for children were opened in the republic (in Cholpon-Ata and Chon-Saroy). school age and pioneers, in particular, the Cholpon-Ata sanatorium for 100 people on the shore of Lake Issyk-Kul for children with tuberculosis intoxication, bronchoadenitis, and tuberculosis of the lymph glands. One of the founders of the service for the protection of motherhood and infancy in Kyrgyzstan was the doctor I.A. Lazhenitsin. A.A. Pokrovsky, who arrived in Pishpek in 1924 from Saratov, can rightly be considered the first pediatrician - the organizer of the pediatric business in Kyrgyzstan. He launched an active work to provide medical care to children.

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BASIC SCIENCE AND

CLINICAL MEDICINE

Tenth All-Russian

young researchers
"Man and his health"
St. Petersburg

The Russian Academy of Sciences
Scientific Council of the Russian Academy of Sciences for Physiological Sciences

FUNDAMENTAL
And
CLINICAL MEDICINE
Tenth All-Russian

biomedical conference

young researchers

"Man and his health"

Chairman S.V. Petrov, MD, Professor

Deputy Chairmen N.P. Veselkin, Corr. RAS

O.V. Fionik, Candidate of Medical Sciences, Associate Professor
Members of the organizing committee E.K. Aylamazyan, Academician of the Russian Academy of Medical Sciences

Yu.V. Natochin, Academician of the Russian Academy of Sciences

N..N. Petrova, MD

Program Committee A.V. Balakhonov, Ph.D., Associate Professor

L.G. Magazanik, Corresponding Member RAS

YES. Niauri, MD, Professor

A.G. Obrezan, MD, Professor

N.N. Petrova, MD

O.V. Fionik, Candidate of Medical Sciences, Associate Professor P.K.

L.P. Churilov, Candidate of Medical Sciences, Associate Professor

S.D. Sheyanov, Doctor of Medical Sciences, Professor

A.N. Shishkin, MD, professor

M.V. Erman, MD, Professor

PC. Yablonsky, MD

Editorial board I.P. Mavidi, PhD

E.R. Khalitova

INTERRELATIONSHIP OF CLINICAL

AND CYTOGENETIC DISORDERS

IN CHILDHOOD CEREBRAL PALSY

D.V. Abdullatypova, class. ord.

Kazan State Medical University,

Department of Neurology, Neurosurgery with a course of medical genetics. Kazan, Russia
Objective: to study the relationship between clinical and cytogenetic disorders in cerebral palsy (CP).

Research material. 71 children with various forms of cerebral palsy and 40 healthy individuals were examined. The study included children with intact intelligence studying in a specialized boarding school for children with cerebral palsy. All patients were divided into clinical forms of the disease: hyperkinetic - 13 people. (18.3%), hemiparetic - 25 people. (35.2%) and spastic diplegia - 33 people. (46.5%).

Results. The scoring of the severity of clinical manifestations of cerebral palsy revealed that the most severe changes in self-care, motor deficit, sensory functions are significantly more often determined in children with hyperkinetic form of cerebral palsy, compared with other forms (p

The average values of EM in all forms of cerebral palsy significantly exceeded the spontaneous level of cytogenetic disorders in the control group 0.21% and 0.08%, respectively (p

PECULIARITIES OF THE PERFORMANCE OF SPECIFIED MOTOR ACTIONS WHEN LEFT-HANDED AND RIGHT-HANDED PERCEPTIONS OF DIFFERENT NATURE FEEDBACK

A.P. Abramova, student

Purpose: to analyze the difference in the performance of precision movements when left-handed and right-handed people perceive information feedback of a verbal and formalized nature.

INFLUENCE OF SOME RISK FACTORS OF EARLY DYSONTOGENESIS ON MEMORY DEVELOPMENT IN HIGH SCHOOL STUDENTS

M.A. Abramova, stud.

Pomor State University

them. M.V. Lomonosov, Faculty of Psychology, Department of Psychology. Arkhangelsk, Russia

In the course of scientific work, 24 people aged 15-16 years (12 boys and 12 girls) were examined, studying at secondary school No. 50 in Arkhangelsk and not having a history of severe neurological disorders. At the first stage of the study, the most common risk factors for early dysontogenesis in high school students were identified using a questionnaire developed at the Research Institute of Age Physiology of the Russian Academy of Education. At the second stage, methods were selected that allow for a comprehensive assessment of the psychophysiological development of memory in an individual child: the “10 words” test (auditory short-term memory), the Bernstein test “9 geometric shapes” (short-term visual memory), the method of reproducing differently perceived words ( leading memory type).

A survey of parents of high school students revealed that 83.33 ± 1.54% of children have risk factors in early development: toxicosis of the first half of pregnancy, mother's age, artificial feeding of a child from birth, taking medications during pregnancy, maternal morbidity during pregnancy .

INTERNATIONAL BIOLOGICAL HEALTH

SCIENTIFIC CONFERENCE OF YOUNG SCIENTISTS

"FUNDAMENTAL SCIENCE AND CLINICAL MEDICINE"

(Annual All-Russian conference "Man and his health")

20 April 2019 will take placeXXII International Biomedical Scientific Conference of Young Researchers " Fundamental Science and clinical medicine. Man and his health

Location: St. Petersburg State University, Building of the Twelve Collegia (Universitetskaya nab. 7-9), Auditorium, Petrovsky hall.

Schoolchildren, students, residents, graduate students, young scientists (under the age of 35 full years) are invited to participate. Works devoted to a wide range of problems in all branches of clinical and preventive medicine, as well as morphology, physiology, pathology, pharmacology, biophysics, bioinformatics, biomedical cybernetics, biochemistry, and genetics are accepted. Sections are devoted to biomedicine and clinical medicine, a special seminar is planned under the auspices of the International Society of Pathophysiologists. The purpose of the conference is to attract young researchers to solve urgent problems of modern science, to integrate higher education and fundamental science. From the submitted works, oral and poster presentations will be selected. Abstracts of the conference reports will be published in the ongoing publication of St. Petersburg State University Fundamental Science and Clinical Medicine (Fundam. Nauka Klin. Med.), ISSN 2221-5654, volume 22.

Abstracts are accepted until March 1, 2019 and can only be submitted through automatic system registration of participants and submission of materials.

April 14, 2018 in St. Petersburg state university XXI International Biomedical Scientific Conference of Young Researchers “Fundamental Science and Clinical Medicine. Man and his health.

Location: St. Petersburg State University, Universitetskaya nab. 7-9, Assembly Hall, Petrovsky Hall.

April 22, 2017 XX International Biomedical Scientific Conference of Young Researchers “Fundamental Science and Clinical Medicine. Man and his health.

Venue – St. Petersburg State University, Building of the Twelve Collegia (Universitetskaya nab. 7-9), Assembly and Petrovsky halls.

The purpose of the conference is to attract young researchers to solve urgent problems modern science, integration of higher education and fundamental science. From the submitted works, oral and poster presentations will be selected.

Abstracts are accepted until March 1, 2017 and can be served only through an automatic system for registering participants and submitting materials.

Abstracts that do not follow these rules will not be accepted. After consideration of the abstracts by the editorial board, the authors will receive a notification about participation in the conference and about the oral or poster form of the report.

Email: This email address is being protected from spambots. You must have JavaScript enabled to view.
NB! Email address mail is indicated only for questions, abstracts by e-mail. mail cannot be accepted.

Abstracts of the international biomedical scientific conference "Fundamental Science and Clinical Medicine" are available for download:

On April 23, 2016, St. Petersburg State University hostedXIX International medical-biological conference of young researchers "Fundamental science and clinical medicine. Man and his health".

The conference was attended by more than 500 young researchers and leading scientists from 174 scientific, educational and medical organizations in 75 cities of Russia, as well as Belarus, Great Britain, Vietnam, Jordan, Kazakhstan, China, Moldova, Namibia, Nigeria, Ukraine, Uzbekistan, Finland, France , Croatia.

36 oral presentations and 174 poster presentations were presented at the conference.

In the ongoing edition Fundamental Science and Clinical Medicine: Abstracts of the XIX International Biomedical Conference of Young Researchers. - St. Petersburg: Publishing House of St. Petersburg State University, 2016. - 694 p. [Fundam. science wedge. honey. - 2016. - v. 19. - p. 1–694] published abstracts of 586 papers by more than 900 young researchers and lectures by leading scientists.

As a result of the conference, the inter-university jury with the participation of representatives of the Russian Academy of Sciences, medical and pharmaceutical universities of St. Petersburg, scientific and professional medical and natural science societies, the Palace of Youth Creativity and the medical book publishing house "ELBI-SPb" awarded diplomas and prizes to the best works.

XVIII International Biomedical Conference of Young Researchers “Fundamental Science and Clinical Medicine. Man and his health”, dedicated to the 20th anniversary of the Medical Faculty of St. Petersburg State University

On April 18, 2015 at St Petersburg University, in the building of the Twelve Collegia, the XVIII International Medical and Biological Conference of Young Researchers was held
«Fundamental science and clinical medicine. Man and His Health”, dedicated to the 20th anniversary of the Medical Faculty of St. Petersburg State University, where young scientists presented their papers on topical fundamental and applied issues of experimental, clinical, preventive medicine and related biomedical sciences.

This year the conference was attended by over 500 young researchers and leading scientists from almost 200 organizations in 75 cities of Russia, as well as Bangladesh, Belarus, Israel, Kazakhstan, Moldova, Mongolia, Namibia, Serbia, USA, Ukraine, Uzbekistan, Croatia, Jamaica, Japan.
At the conference itself, 35 oral presentations and more than 160 poster presentations were presented, in the ongoing publication Fundamental Science and Clinical Medicine - Man and His Health: Abstracts of the XVIII International Medical and Biological Conference of Young Researchers - 540 papers by 882 young researchers and lectures by leading scientists.

On April 19, 2014 at St. Petersburg State University, in the building of the Twelve Collegia, the All-Russian medical and biological scientific conference of young scientists with international participation "Fundamental Science and Clinical Medicine" (XVII All-Russian Conference "Man and His Health") was held, at which young scientists presented works, dedicated to topical fundamental and applied issues of experimental, clinical, preventive medicine and related biomedical sciences.

The conference was attended by more than 500 young researchers, from schoolchildren to associate professors, from 144 organizations in 75 cities of Russia, as well as Austria, Belarus, Germany, Kazakhstan, Kyrgyzstan, China, Moldova, USA, Tajikistan, Ukraine, Uzbekistan. At the conference itself, 36 oral presentations and more than 160 poster presentations were presented, in the ongoing publication Fundamental Science and Clinical Medicine - Man and His Health: Abstracts of the XVII All-Russian Medical and Biological Conference of Young Researchers (with international participation). - St. Petersburg: Publishing House of St. Petersburg State University, 2014. - 564 p. [Fundam. science wedge. honey. - 2014. - T. 17. - S. 1–564] - 477 works of 758 young researchers and lectures by leading scientists were published.

As a result of the conference, the winners were awarded diplomas of various denominations in the categories of oral and poster presentations on clinical and biomedical topics, as well as special prizes and diplomas from scientific and professional societies - the St. Petersburg branch of the International Society of Pathophysiologists (ISP), the Russian Physiological Society named after I. P. Pavlov, St. Petersburg City Palace of Youth Creativity, publishing house "Elbi-SPb", Bekhterev Psychiatric Society, St. Petersburg branch of the All-Russian Society of Anatomists, Histologists, Embryologists, International Academy of Sciences Russian Section (Health and Ecology), Pirogov Surgical Society, St. Petersburg Society of Naturalists. The winners included young scientists from 12 cities and 33 different scientific and educational institutions Belarus, Germany, Kazakhstan, Russia and Ukraine, and St. Petersburg State University is represented among the winners by 3 faculties.

On April 20, 2013 at St. Petersburg State University, in the building of the Twelve Collegia, the All-Russian medical and biological scientific conference of young scientists with international participation "Fundamental Science and Clinical Medicine" (XVI All-Russian Conference "Man and His Health") was held.

The conference was attended by more than 400 young researchers, from schoolchildren to associate professors, from 142 organizations in 63 cities of Russia, as well as Azerbaijan, Belarus, Germany, Georgia, Iraq, Iran, Kazakhstan, Kyrgyzstan, China, Latvia, Moldova, Mongolia, Pakistan, Tajikistan, Ukraine, Uzbekistan, Sweden. At the conference itself, 36 oral presentations and more than 120 poster presentations were presented, in the ongoing publication Fundamental Science and Clinical Medicine - Man and His Health: Abstracts of the XVI All-Russian Medical and Biological Conference of Young Researchers (with international participation). - St. Petersburg: Publishing House of St. Petersburg State University, 2013. - 512 p. [Fundam. science wedge. honey. - 2012. - V. 16. - P. 1–512]., abstracts of 430 works of 689 young researchers selected by reviewers were published. The works are devoted to topical fundamental and applied issues of experimental, clinical, preventive medicine, as well as related biomedical sciences.

The All-Russian Medical and Biological Scientific Conference of Young Researchers "Fundamental Science and Clinical Medicine - Man and His Health" has been held at St. Petersburg State University annually since 1997. The conference gathers authors and participants from all over Russia and from other countries. About 600 people participate in the conference every year. During the conference, sessions of oral and poster presentations on clinical and biomedical topics are held. As part of the conference, leading scientists traditionally give lectures to young scientists.

Schoolchildren, students, interns, residents, graduate students, young scientists (under the age of 35) are invited to participate in the conference. Works devoted to a wide range of problems of morphology, physiology, pathology, pharmacology, biophysics, biochemistry, genetics, all branches of clinical and preventive medicine are accepted.

The purpose of the conference is to involve young researchers in solving urgent problems of modern science, the integration of higher education and fundamental science. From the submitted works, oral and poster presentations will be selected. Abstracts of the conference reports will be published in the ongoing publication of St. Petersburg State University Fundamental Science and Clinical Medicine (Fundam. Nauka Klin. Med.), ISSN 2221-5654.

Abstract map 201 3

Conference News:

On April 21, 2012, the XV Anniversary All-Russian Medical and Biological Conference of Young Researchers (with international participation) “Fundamental Science and Clinical Medicine. Man and his health.

The conference was attended by more than 570 young researchers, from schoolchildren to associate professors, from 100 organizations in 46 cities of Russia, as well as Belarus, Iran, China, Kazakhstan, Latvia, Moldova, Mongolia, Uzbekistan, Ukraine, South Ossetia. At the conference itself, 36 oral presentations were heard and more than 70 poster presentations were presented, about 400 papers were published in the proceedings of the conference (Fundam. science of clinical medicine -2012. - vol. 15. - p. 1 - 412, ISSN 2221 - 5654) selected by reviewers.

The jury members are representatives of the medical, dental, biological and soil and chemical faculties of St. Petersburg State University, as well as St. Petersburg State Medical University. acad. I.P. Pavlova, VmedA them. CM. Kirov, SPbGPMA, five scientific and professional societies, the Palace of Youth Creativity, the medical book publishing house "ElBi-SPb" - were awarded 37 diplomas of various denominations in different categories following the results of the conference. The winners included young researchers from Russia, Belarus, China, and Kazakhstan.